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In 1959, Saltztein collated a number of published reports with seven of his own cases and proposed the term “drug-induced pseudolymphoma” to describe this condition.[5] In the 1960s came reports of a syndrome similar to Saltztein's pseudolymphoma, but with rash and fever in addition to lymphadenopathy, and in 1988, the term “anticonvulsant hypersensitivity syndrome” was first used to label this specific entity.[6] These group of syndromes had been historically described by various names which include Dilantin hypersensitivity reaction,’ “phenytoin/Dilantin syndrome,” “Kawasaki-like syndrome,” “mononucleosis-like syndrome,” pseudolymphoma, febrile mucocutaneous syndrome, graft-versus-host–like illness, Kawasaki-like illness, hypersensitivity mimicking infectious mononucleosis-like illness, multisystem hypersensitivity reaction, and drug-induced aseptic meningitis.[7,8] In 1998, the nomenclature was further confused by Sontheimer's suggestion of “drug-induced delayed multiorgan hypersensitivity syndrome” to describe this disorder.[4] At the same time, Bocquet et al coined the term, “drug rash with eosinophilia and systemic symptoms,” for those with systemic involvement, which subsequently got more acceptance.[9] A dermatosis is usual but not mandatory in DRESS

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